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Abstract #3899

Brain Tissue Response to Chronically Implanted NMR Microcoils

Aziz Kadjo1, Jean-christophe Brisset1, Minh-Dung Hoang1,2, Patrick Poulichet3, Colette Rousset4, Abdennasser Fakri3, Youssef Z. Wadghiri, Marlne Wiart1, Lionel Rousseau3, Raymond Cespuglio4, Andre Briguet1, Danielle Graveron-Demilly1, Latifa Fakri-Bouchet1

1Universit Lyon1, CREATIS-LRMN CNRS UMR 5220, INSERM U630, Villeurbanne, France; 2 NYU, New York University, School of Medicine, Center for Biomedical Imaging, 10016 NY, United States; 3ESIEE Paris, Lab. de Technologie avance en microlectronique ESYCOM,EA 2552, Noisy Le Grand, France; 4Universit Lyon1, Lab. Radicaux libres/substrats nergie et physiopathologie crbrale. EA 4170, Lyon, France

New generation of implantable microcoils proposed for localized spectroscopic studies of NMR observable cerebral metabolites into 2mm3 region of interest Latero Dorsal Tegumentum (LDT), aims at pushing limits of in vivo detection. However microantenna active part introduction into the brain can generate irreversible damage and inflammation that can distort spectroscopic measurements. This longitudinal study was performed on two healthy cohorts of implanted and control rat via MRI and confirmed by histopathology. The results show brain tissue response against implantable NMR microcoil and demonstrate the limited brain tissue reaction associated to the chronic microcoils implantion.