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Abstract #3977

Differences Between Bipolar Disorder Patients and Control Subjects Using a New SPM Toolbox for Track-Based Spatial Statistics

Jadwiga Rogowska1, M Lopez-Larson2, M Bielecki3, Piotr Bogorodzki3, D Yurgelun-Todd2

1Brain Imaging Center, McLean Hospital/Harvard Medical School, Belmont, MA, United States; 2The Brain Institute, University of Utah, Salt Lake City, UT, United States; 3Institute of Radioelectronics, Warsaw Technical University, Warsaw, Poland

Human imaging studies have implicated structural and functional abnormalities in patients with bipolar disorder. In this study we examined the differences in diffusion tensor imaging (DTI) data between bipolar patients and healthy control subjects using the methodology of Track-Based Spatial Statistics and our newly developed SPM's Toolbox. We found that bipolar disorder patients had significantly lower fractional anisotropy values within the cingulate gyrus when compared to control subjects. Our findings suggest that DTI techniques can highlight microstructural abnormalities in the brain, not evident on conventional MRI, which may be associated with the neuropathology of this disorder.