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Abstract #3981

A DTI Study of Developmental Brain Changes During Puberty

Jee Eun Lee1, Nicholas Lange2, Frances Haeberli1, Richard J. Davidson1, Andrew L. Alexander1

1Waisman Center, University of Wisconsin, Madison, WI, United States; 2Neurostatistics Laboratory, Belmont, MA, United States

DTI measures of normal children during their pubertal period were investigated. When age was matched for the pre-adolescence group (Tanner score 1) and adolescence (Tanner score 3&4) group, there was no significant DTI measures between these groups. However, DTI measures showed strong correlations with age for the entire subjects. Our study may indicate that changes in DTI measures over age are not driven by puberty-related changes directly.