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Abstract #3987

Constant and Variable Features of White Matter Anatomy in the Human Brain: An in Vivo Diffusion Tractography Study

Michel Thiebaut de Schotten1, Flavio Dell'acqua, Dominic ffytche2, Matthew Allin3, Muriel Walshe3, Robin Murray4, Steve Williams2, Declan Murphy1, Marco Catani2

1Brain Maturation, Institute of Psychiatry, London, United Kingdom; 2Centre for Neuroimaging Sciences, Institute of Psychiatry, London; 3Department of Psychiatry, Institute of Psychiatry, London; 4Department of Psychological Medecine, Institute of Psychiatry, London

Increasing knowledge of white matter organization has recently been derived from diffusion tensor tractography but access to this knowledge has often been limited to Diffusion Tensor Imaging (DTI) experts. Therefore a tractography atlas of the human brain pathways is timely for a better comprehension of brain function. However, this endeavour may be compromised by methodological limitations of the DTI technique and the high degree of inter-individual anatomical variability. Here we combine group effect maps with a spatial overlap approach to develop a 3D probabilistic atlas that provides comprehensive information about inter-subject variability and general morphology of the tract.