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Abstract #3991

Multi-Site Investigation of DTI Reproducibility

Karl Gerard Helmer1, Ming-Chung Chou2, Allen Song3, Jessica Turner4, Barjor Gimi5, Susumu Mori6

1Radiology, Massachusetts General Hospital, Charlestown, MA, United States; 2Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan; 3Duke University, Durham, NC, United States; 4University of California, Irvine, Irvine, CA, United States; 5UT Southwestern Medical Center at Dallas, Dallas, TX, United States; 6Johns Hopkins University School of Medicine, Baltimore, MD, United States

The addition of diffusion tensor imaging to the protocol of multi-site studies has become more common in recent years. However, few studies have been performed on the reproducibility of tensor metrics across site and scanner manufacturer. We present data using scanners from Siemens, Philips, and GE and look at the behavior of the fractional anisotropy as decreasing amounts of data and/or diffusion-weighted directions are used in the tensor calculation. The methods used in this study are also suitable for the site-reliability characterization before a multi-site study is begun or after upgrades during the study.