Jrgen Finsterbusch1,2
1Department of Systems Neuroscience ,
University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Neuroimage
Nord, University Medical Centers Hamburg-Kiel-Lbeck, Hamburg-Kiel-Lbeck,
Germany
Double-wave-vector
diffusion-weighting experiments where two diffusion weighting periods are
applied successively in a single acquisition are a promising tool to
investigate tissue microstructure, e.g. cell or compartment sizes. However,
for the long gradient pulse durations required on whole-body MR systems the underlying
signal modulation with the angle between the two wave vectors may be small
which hampers the detectability of the effect. Here, it is shown that
multiple concatenations of the two diffusion weightings in a single
experiment can yield considerably higher signal modulations than expected
theoretically because shorter gradient pulses are sufficient to achieve the
desired diffusion weighting.