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Abstract #4013

A Multi-Structural Fiber Crossing Anisotropic Diffusion Phantom for HARDI Reconstruction Techniques Validation

Danilo Scelfo1,2, Laura Biagi1, Lucia Billeci1,3, Michela Tosetti1

1MR Laboratory, Stella Maris Scientific Institute, Pisa, Italy; 2Department of Physics, University of Pisa, Pisa, Italy; 3Inter-departmental Research Center E. Piaggio, University of Pisa, Pisa, Italy

There is significant interest in evaluating the performance and reliability of white matter fiber tractography algorithms. DTI-based fiber tracking gives insights into the complex architecture of the brain. However, it is well known that it presents a number of limitations, especially in presence of fiber crossing, The validation of fiber reconstruction by these different approaches remains challenging and requires suitable test phantoms. An experimental model with different fiber crossing configurations has been projected and realized (PIVOH, Phantom with Intra-Voxel Orientation Heterogeneity), in order to simulate the structural complexity of the white matter, in correspondence of fiber intersection