Danilo
Scelfo1,2, Laura Biagi1, Lucia Billeci1,3,
Michela Tosetti1
1MR Laboratory, Stella Maris Scientific
Institute, Pisa, Italy; 2Department of Physics, University of
Pisa, Pisa, Italy; 3Inter-departmental Research Center E.
Piaggio, University of Pisa, Pisa, Italy
There
is significant interest in evaluating the performance and reliability of
white matter fiber tractography algorithms. DTI-based fiber tracking gives
insights into the complex architecture of the brain. However, it is well
known that it presents a number of limitations, especially in presence of
fiber crossing, The validation of fiber reconstruction by these different
approaches remains challenging and requires suitable test phantoms. An
experimental model with different fiber crossing configurations has been
projected and realized (PIVOH, Phantom with Intra-Voxel Orientation
Heterogeneity), in order to simulate the structural complexity of the white
matter, in correspondence of fiber intersection