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Abstract #4022

3D Tracking of Magnetic Pathways in White Matter Based on Magnetic Susceptibility Anisotropy

Chunlei Liu1,2, Yi Jiang3, G. Allan Johnson3

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 2Radiology, Duke University, Durham, NC, United States; 3Center for In Vivo Microscopy, Duke University, Durham, NC, United States

We propose a method for tracking a magnetic network existing in the white matter. The proposed method utilizes a previously unexplored magnetic property of white matter fibers. We found that the magnetic moment of white matter varies significantly when measured at different brain orientations with respect to the external field. This orientation dependence can be modeled by an apparent susceptibly tensor. Decomposing this tensor into its eigensystem revealed a spatially coherent network. Following the orientation of the major eigenvector, we were able to map distinctive magnetic pathways in 3D. The relationship between the magnetic network and fiber pathways is discussed.