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Abstract #4042

Assessment of Myocardial Heterogeneity Using the Supertoroid-Based Representation of Dt-Mri

Choukri Mekkaoui1,2, Marcel Jackowski3, Roberto Martuzzi1, Donald Dione1, Albert Sinusas1

1Yale University School of Medicine, New Haven, CT, United States; 2Harvard Medical School, Boston, MA, United States; 3University of So Paulo

Supertoroids are a novel DT-MRI representation that provides indices of diffusivity (toroidal volume:TV) and anisotropy (toroidal curvature:TC). The purpose of this study is to establish the normal myofiber structure of the left ventricle (LV) using toroid-based indices and compare to traditional diffusion indices in normal porcine hearts. These new indices showed that the LV macrostructure was heterogeneous for both diffusivity and anisotropy between segments (Septum, RV/LV junction, and Free Wall) and within levels (basal, mid-ventricular, and apical). TV and TC demonstrate that diffusivity and anisotropy measures are complimentary, which may enhance the understanding of LV macrostructure in the normal heart.