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Abstract #4044

Stability of Repeat Measures of CBF in Aged Tg2576 and Wild Type Mice via CASL

James A. Goodman1, Zhiyong Xie2

1BioImaging Center of Emphasis, Pfizer, Inc., Groton, CT, United States; 2BioImaging Center of Emphasis, Pfizer, Inc, Groton, CT, United States

Cerebral blood flow is a physiological parameter that varies within populations and is subject to significant physiological noise. In order to quantify the test/retest stability of CBF measurement via MR, arterial spin labeling was performed three times in three different imaging session on each of five aged App(+)Tg2576 mice (TG) and five age-matched controls (WT). The coefficient of variation of repeat measurements within each animal was about two times larger in the TG group than in the WT group. Since measurements from both groups were interspersed, it appears as though physiological noise was the dominant noise component in these measurements.