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Abstract #4062

Correction of Partial Volume Effects in PASL Perfusion Measurements

Marco Pimentel1, Pedro Vilela2, Ins Sousa3,4, Patricia Figueiredo3

1Faculdade de Cincias e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal; 2Imaging Department, Hospital da Luz, Lisbon, Portugal; 3Instituto Superior Tcnico, Lisbon, Portugal; 4Healthcare Sector, Siemens, S.A., Portugal

We developed a simple model to correct for partial volume effects (PVE's) in ASL imaging and studied its performance in the estimation of grey matter (GM) and white matter (WM) perfusion, as well as in the application of ASL to brain activation measurements in fMRI, in a group of 15 healthy subjects at 3T. Our results reveal the importance of performing an accurate segmentation in order to achieve a good correction of PVEs, which can strongly influence the measured GM to WM perfusion ratio and also the perfusion changes due to activation.