Marco
Pimentel1, Pedro Vilela2, Ins Sousa3,4,
Patricia Figueiredo3
1Faculdade
de Cincias e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal; 2Imaging
Department, Hospital da Luz, Lisbon, Portugal; 3Instituto Superior
Tcnico, Lisbon, Portugal; 4Healthcare Sector, Siemens, S.A.,
Portugal
We
developed a simple model to correct for partial volume effects (PVE's) in ASL
imaging and studied its performance in the estimation of grey matter (GM) and
white matter (WM) perfusion, as well as in the application of ASL to brain
activation measurements in fMRI, in a group of 15 healthy subjects at 3T. Our
results reveal the importance of performing an accurate segmentation in order
to achieve a good correction of PVEs, which can strongly influence the
measured GM to WM perfusion ratio and also the perfusion changes due to
activation.