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Abstract #4067

Separation of Intravascular Signal in Multi-Inversion Time Arterial Spin Labelling MRI

Michael A. Chappell1, Bradley J. MacIntosh1,2, Manus J. Donahue1, Matthias Gnther3,4, Peter Jezzard1, Mark W. Woolrich1

1FMRIB Centre, University of Oxford, Oxford, United Kingdom; 2Imaging Research, Sunnybrook Research Institute, Toronto, Canada; 3Department of Neurology, Universittsklinikum Mannheim, University of Heidelberg, Mannheim, Germany; 4mediri GmbH, Heidelberg, Germany

An important artefact in ASL measurements arises from labelled water that is still intravascular (IV) at the time of imaging. One solution is the application of flow suppression. An alternative, for multi-TI ASL, is to include the IV component within the Kinetic model whilst ensuring that this component is only used where the data supports it. In this work the two alternatives were compared in both healthy subjects and patients with stenoses. The model fitting approach was found to be a viable alternative to flow suppression, making it suitable where flow suppression is not desirable or feasible.