Michael A. Chappell1, Bradley J. MacIntosh1,2,
Manus J. Donahue1, Matthias Gnther3,4, Peter Jezzard1,
Mark W. Woolrich1
1FMRIB Centre, University of Oxford,
Oxford, United Kingdom; 2Imaging Research, Sunnybrook Research
Institute, Toronto, Canada; 3Department of Neurology,
Universittsklinikum Mannheim, University of Heidelberg, Mannheim, Germany; 4mediri
GmbH, Heidelberg, Germany
An
important artefact in ASL measurements arises from labelled water that is
still intravascular (IV) at the time of imaging. One solution is the
application of flow suppression. An alternative, for multi-TI ASL, is to
include the IV component within the Kinetic model whilst ensuring that this
component is only used where the data supports it. In this work the two
alternatives were compared in both healthy subjects and patients with
stenoses. The model fitting approach was found to be a viable alternative to
flow suppression, making it suitable where flow suppression is not desirable
or feasible.
Keywords