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Abstract #4084

Increased Basal Ganglia Metabolism by the Dopamine Antagonist Metoclopramide Measured by Perfusion MRI

Maria Asuncion Fernandez-Seara1, Maite Aznarez-Sanado1, Franz Heukamp2, Maria Asuncion Pastor1

1Neuroscience, Center for Applied Medical Research. University of Navarra, Pamplona, Navarra, Spain; 2IESE Business School. University of Navarra

The effects on cerebral perfusion of an oral dose of the dopamine antagonist antiemetic Metoclopramide were assessed in a group of young healthy volunteers, using phase contrast imaging and arterial spin labeling perfusion MRI. Metoclopramide significantly reduced mean blood velocity and blood flow through the internal carotid arteries and cerebral blood flow in distributed areas of the cortex. However, Metoclopramide intake selectively increased perfusion in the striatum. A similar perfusion pattern has been observed in patients with Parkinsons disease. Our results suggest that hyperperfusion in the striatum could be a very early marker of PD and that ASL perfusion MRI could aid in the early diagnosis of the disease.