Yi-Ying Wu1,2, Jyh-Wen Chai1,
Chi-Chang Chen1, Ho-Ling Liu2,3
1Department of Radiology, Taichung
Veterans General Hospital, Taichung, Taiwan; 2Institute of Medical
Physics and Imaging Science, Chang Gung University, Taoyuan, Taiwan; 3MRI
Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Disruption
of blood-brain barriers in brain lesions usually causes difficulty in
accurate quantification if rCBV in DSC-MRI. In this study, a simulated model
was proposed to evaluate the dependence of the pre-loading dose on the rCBV
measurements. The results showed an underestimate of rCBV without pre-loading
or with low pre-loading dose at 1.5T. The underestimation was improved with
larger pre-loading dose. Significant overestimation of rCBV happened with
pre-loading of contrast agents at 3.0T, particularly with higher dose and a
longer TE. In conclusion, this experiment provided important evidence that
how the pre-loading dose affect the accurate quantification of rCBV
measurement.