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Abstract #4114

Effects of Pre-Loading Dose on DSC-MRI with Contrast Agent Extravasation

Yi-Ying Wu1,2, Jyh-Wen Chai1, Chi-Chang Chen1, Ho-Ling Liu2,3

1Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; 2Institute of Medical Physics and Imaging Science, Chang Gung University, Taoyuan, Taiwan; 3MRI Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

Disruption of blood-brain barriers in brain lesions usually causes difficulty in accurate quantification if rCBV in DSC-MRI. In this study, a simulated model was proposed to evaluate the dependence of the pre-loading dose on the rCBV measurements. The results showed an underestimate of rCBV without pre-loading or with low pre-loading dose at 1.5T. The underestimation was improved with larger pre-loading dose. Significant overestimation of rCBV happened with pre-loading of contrast agents at 3.0T, particularly with higher dose and a longer TE. In conclusion, this experiment provided important evidence that how the pre-loading dose affect the accurate quantification of rCBV measurement.