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Abstract #4116

Direct Comparison of Dynamic Susceptibility Weighted MR Perfusion with CT Perfusion in Brain Tumors

Hassan Bagher-Ebadian1,2, Jayant Narang3, James Russel Ewing1, Siamak Pourabdollah Nejad-Davarani1,4, Mohammad Hossein Asgari1, Sona Saksena3, Rajan Jain3

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Physics, Oakland University, Rochester, MI, United States; 3Radiology, Henry Ford Hospital, Detroit, MI, United States; 4Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States

The purpose of this study is comparison of Dynamic susceptibility contrast enhanced MR perfusion (DSC-MRP) and CT Perfusion (CTP) in brain tumors patients in normal as well as abnormal regions. CTP maps were calculated using the Johnson and Wilson Model and DSC-MRP maps were calculated based on conventional singular value decomposition (SVD) technique. The results imply that there is underestimation of all perfusion parameters by SVD technique as compared to CTP mostly due to the fact that DSC-MRP only measures CBV from the microvasculature as well as due to the non-linearity of arterial input function with Contrast Agent (CA) concentration.