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Abstract #4120

Multislice Treatment Planning and Control for Real Time MR-Guided Prostate Ablation with Transurethral Multisectored Ultrasound Applicators

Andrew B. Holbrook1,2, Punit Prakash3, Peter Jones3, Catherine Planey2, Juan M. Santos4,5, Chris J. Diederich3, Kim Butts Pauly2, F. Graham Sommer2

1Bioengineering, Stanford University, Stanford, CA, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Radiation Oncology, UCSF, San Francisco, CA, United States; 4HeartVista, Los Altos, CA, United States; 5Electrical Engineering, Stanford University, Stanford, CA, United States

Targeted prostate ablation with transurethral multisectored ultrasound applicators could be improved with an integrated imaging platform that minimizes procedural setup and treatment time. The purpose of this work was to integrate device localization, prostate-specific planning tools, and multi-slice MR thermometry into a single imaging platform. Various phantom experiments were performed to validate each of these steps. Device localization and MR tracking was validated in a phantom, and an ablation was performed in another phantom with multi-slice thermometry and ROI feedback. The platform successfully measured temperature rises and relayed that data to external power control software that regulated the ablation.