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Abstract #4131

Volumetric Ablation of Tissue Using Magnetic Resonance Imaging Guided High Intensity Focused Ultrasound (MRgFUS) with Feedback Control and Multi-Slice Thermal Monitoring: Initial Experience in a Pig Model

Jiming Zhang1, Ann Marie Marciel2, Tiina Karjalainen3, Ari Partanen4, Charles Mougenot, Amol Pednekar3, Gil Costas5, Jesse Rios5, Fredd Clubb5, John Fischer2, Robert Zurawin6, Pei Hor1, Raja Muthupillai2

1Dept of Physics, University of Houston, Houston, TX, United States; 2Diagnostic and Interventional Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States; 3Clinical Science, Philips Medical Systems, Cleveland, OH, United States; 4Clinical Science, Philips Healthcare, Cleveland, OH, United States; 5Texas Heart Institute; 6Baylor College of Medicine

Preliminary results from a pig model suggest that it is feasible to create volumetric thermal lesions within in-vivo tissue using dynamic movement of the focal point of a High-Intensity Focused Ultasound beam with real-time multi-slice monitoring, and feedback control. The measured thermal dose diameters and lengths correspond closely with planned dose diameters for treatment cell sizes ranging from 4-16 mm in diameter.