Gerlinde
Schmidtke-Schrezenmeier1, Markus Urban2, Sonu Sharma3,
Katharina Landfester2, Hubert Schrezenmeier1, Volker
Rasche3
1Institute for Transfusion Medicine,
University Hospital of Ulm, Ulm, Germany; 2Max-Planck-Institute
for Polymer Research, Mainz, Germany; 3Department of Internal
Medicine II, University Hospital Ulm, Ulm, Germany
Different
iron-loaded nanocapusles (diameter 110nm to 135nm, zeta-potential -28mV to
-55mV) were synthesized by the mini-emulsion process and applied for
efficient labeling of MSCs. The MRI efficiency (T2 and T2* relaxation) and
kinetics of the particles regarding cell uptake and release as well as its
impact on the cell properties were investigated. The visibility of the
labeled cells was investigated over a time period of 14days in an agarose gel
phantom.
Keywords