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Abstract #4190

Poly-L-Lactic Acid (PLLA) Iron Loaded Nanoparticles for MRI Cell Labelling

Gerlinde Schmidtke-Schrezenmeier1, Markus Urban2, Sonu Sharma3, Katharina Landfester2, Hubert Schrezenmeier1, Volker Rasche3

1Institute for Transfusion Medicine, University Hospital of Ulm, Ulm, Germany; 2Max-Planck-Institute for Polymer Research, Mainz, Germany; 3Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany

Different iron-loaded nanocapusles (diameter 110nm to 135nm, zeta-potential -28mV to -55mV) were synthesized by the mini-emulsion process and applied for efficient labeling of MSCs. The MRI efficiency (T2 and T2* relaxation) and kinetics of the particles regarding cell uptake and release as well as its impact on the cell properties were investigated. The visibility of the labeled cells was investigated over a time period of 14days in an agarose gel phantom.