Elena Torres1,
Enzo Terreno1, Roberta Cavalli2, Franco Fedeli3,
Francesco Mainini1, Roberta Napolitano1, Silvio Aime1
1Department of Chemistry and Molecular
Imaging Center, University of Torino, Torino, Italy; 2Department
of Drug Science and Technology, University of Torino, Italy; 3Bioindustry
Park of Canavese, Italy
Liposomes
occupy a leading role in biomedical field being successfully used since a
long time as drug-delivery systems. These nanovesicles can be properly
formulated in order to release the entrapped material as a consequence of a
specific endogenous stimulus (e.g. acidification, change in redox potential
or concentration of specific enzymes) that characterizes the early
asymptomatic stage of many diseases. In this contribution, a novel class of
paramagnetic pH sensitive liposomes with improved formulations are presented
and their basic MRI properties evaluated both in vitro and in vivo on tumor
animal model on mice.
Keywords