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Abstract #4204

Paramagnetic PH Sensitive Liposomes with Improved MRI Properties

Elena Torres1, Enzo Terreno1, Roberta Cavalli2, Franco Fedeli3, Francesco Mainini1, Roberta Napolitano1, Silvio Aime1

1Department of Chemistry and Molecular Imaging Center, University of Torino, Torino, Italy; 2Department of Drug Science and Technology, University of Torino, Italy; 3Bioindustry Park of Canavese, Italy

Liposomes occupy a leading role in biomedical field being successfully used since a long time as drug-delivery systems. These nanovesicles can be properly formulated in order to release the entrapped material as a consequence of a specific endogenous stimulus (e.g. acidification, change in redox potential or concentration of specific enzymes) that characterizes the early asymptomatic stage of many diseases. In this contribution, a novel class of paramagnetic pH sensitive liposomes with improved formulations are presented and their basic MRI properties evaluated both in vitro and in vivo on tumor animal model on mice.