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Abstract #4210

Controlling the Dissolution of MnO Nanocrystals for Time-Dependent T1 MRI Contrast Agents

Yi-Cheng Lee1, Der-Yow Chen2, Stephen J. Dodd2, Nadia Bouraoud2, Alan P. Koretsky2, Kannan M. Krishnan1

1MSE, University of Washington, Seattle, WA, United States; 2NINDS, National Institutes of Health, Bethesda, MD, United States

Manganese based nanoparticles have potential as agents that can be "activated" when taken into cells. It would be advantageous to be able to control the rate of dissolution of Mn based nanoparticles to control T1 contrast signals, in vivo with time. To this end, five different coatings on MnO nanocrystals have been tested to study the release rate of the Mn2+ ions and change in relaxivity at pH 7 compared to pH 5. The MnO@SiO2 particles show the best potential for delaying the release of MRI contrast until specific biological processes have occurred, such as endocytosis.