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Abstract #4212

MRI Probes for Sensing the Extracellular Redox State

Giuseppe Digilio1, Valeria Menchise2, Eliana Gianolio3, Franco Fedeli3, Concetta Gringeri1, Roberta Napolitano3, Carla Carrera3, Valeria Catanzaro3, Silvio Aime3

1DISAV, University of Eastern Piedmont, Alessandria, AL, Italy; 2Institute for Bioimages and Biostructures, CNR, Naples, Italy; 3Department of Chemistry IFM, University of Turin, Turin, Italy

Exofacial protein thiols exposed on the cell surface are responsive to the redox state of the extracellular milieu. They can be exploited as anchorage points for suitably designed Gd-based MRI probes, allowing for the visualization of hypoxic tumor regions.