Julio
Acosta-Cabronero1,2, Guy B. Williams1, George Pengas2,
Peter J. Nestor2
1Wolfson Brain Imaging Centre,
Department of Clinical Neurosciences, University of Cambridge, Cambridge,
Cambridgeshire, United Kingdom; 2Neurology Unit, Department of
Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire,
United Kingdom
The
splenium and genu of the corpus callosum (CC), which contain millions of
inter-hemispheric fibres, were found to be abnormal in early AD. In this
study, we analysed the behaviour of several DTI measures in the subregions of
the midline CC and assessed their relationship with global cognitive data. We
found that in both splenium and genu, axial and mean diffusion were better
predictors of the disease, whereas radial diffusion and particularly,
fractional anisotropy exhibited strong correlations with cognitive
performance in the splenium only. The results suggest that the
neurodegenerative processes affecting the splenium are different than in the
genu.
Keywords