Susanne G. Mueller1, Andreas Ebel1,
Jerome Barakos2, Cathy Scanlon1, Ian Cheong1,
Daniel Finaly1, Paul Garcia3, Michael W. Weiner1,
Kenneth D. Laxer2
1Dept. of Radiology and Biomedical Imaging, UCSF,
Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, United
States; 2Pacific Epilepsy Program, Califronia Pacific Medical
Center; 3Department of Neurology, UCSF
14
TLE with mesial temporal lobe sclerosis (TLE-MTS)and 14 TLE with normal
appearing hippocampi (TLE-no) and 18 healthy volunteers were studied with a
whole brain 3D EPSI at 4T. Widespread NAA/(Cr+Cho) reductions showing a
considerable intersubject variability were found in both groups. The
distribution of these abnormalities was different in the two TLE groups.
These findings indicate that TLE-MTS and TLE-no are metabolically
heterogeneous and might even represent different TLE entities.
Keywords