Meeting Banner
Abstract #4270

Widespread and Different Distribution of Extrafocal NAA/(Cr+Cho) Reductions in Mesial Temporal Lobe Epilepsy (TLE) with and Without Mesial Temporal Sclerosis

Susanne G. Mueller1, Andreas Ebel1, Jerome Barakos2, Cathy Scanlon1, Ian Cheong1, Daniel Finaly1, Paul Garcia3, Michael W. Weiner1, Kenneth D. Laxer2

1Dept. of Radiology and Biomedical Imaging, UCSF, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, United States; 2Pacific Epilepsy Program, Califronia Pacific Medical Center; 3Department of Neurology, UCSF

14 TLE with mesial temporal lobe sclerosis (TLE-MTS)and 14 TLE with normal appearing hippocampi (TLE-no) and 18 healthy volunteers were studied with a whole brain 3D EPSI at 4T. Widespread NAA/(Cr+Cho) reductions showing a considerable intersubject variability were found in both groups. The distribution of these abnormalities was different in the two TLE groups. These findings indicate that TLE-MTS and TLE-no are metabolically heterogeneous and might even represent different TLE entities.