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Abstract #4273

In Vivo Longitudinal Monitoring of Blood Flow Alterations in TG2576 Mouse Model of Alzheimer's Disease

F Kara1, N Braakman1, M A. van Buchem2, H JM de Groot1, R Schliebs3, A Alia1

1Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands; 3Department of Neurochemistry, University of Leipzig, Leiden, Netherlands

In this study we longitudinally monitored, the blood flow alterations in TG2576 mouse model of Alzheimer's disease using MR angiography. Blood flow alterations were clearly increased in transgenic mice over time. Flow defects in middle cerebral artery were seen already at the age of 8 month when there was no cerebral amyloid angiopathy (CAA) was observed. In anterior cerebral artery the flow alterations were visible at the age of 19 months and were correlated with CAA as well as with high plaque deposition in the brain tissues. Our results show that blood flow defects are present long before vascular deposition of Aβ takes place in this mouse model.