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Abstract #4275

Anatomical Connectivity Mapping Quantifies Neuroplastic Activity of Anticholinesterase Treatments in Patients with Ad

Marco Bozzali1, Tommaso Gili2,3, Laura Serra1, Bruno Maraviglia1,3, Carlo Caltagirone4,5, Karl Embleton6, Geoff J. M. Parker7, Mara Cercignani1

1Neuorimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2MarbiLab, Enrico Fermi Centre, Rome, Italy; 3Dept of Physics, University of Rome "La Sapienza", Rome, Italy; 4Department of Clinical and Behavioural Neurology, Santa Lucia Foundation, Rome, Italy; 5Dept of Neuroscience, University of Rome "Tor Vergata"; 6Cognition and Cognitive Neuroscience Group, School of Psychological Sciences, University of Manchester, United Kingdom; 7Imaging Science & Biomedical Engineering and the Biomedical Imaging Institute, University of Manchester, United Kingdom

This study assesses WM structural connectivity based on an index derived from diffusion MRI in a group of patients with Alzheimer's disease (AD), in a group of patients with amnestic mild cognitive impairment and in a group of healthy control, in order to investigate whether structural connectivity is altered in AD. The unexpected finding of increased anatomical connectivity in several subcortical areas of patients with AD but not in those with mild cognitive impairment might be explained by the neurotrophic and neurorestorative properties of the cholinesterase inhibitors assumed by these patients, although more investigations are needed.