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Abstract #4292

Breath-Hold Regulated Blood Oxygenation-Level Dependent MRI and Vascular Space Occupancy MRI of Brain Tumors

Yuan-Yu Hsu1,2, Wan-Chun Kwan3, Kun-Eng Lim1,2, Ho-Ling Liu4,5

1Dept. of Medical Imaging, Buddhist Tzu Chi General Hospital-Taipei Branch, Xindian, Taipei, Taiwan; 2School of Medicine, Tzu Chi University, Hualien, Taiwan; 3Dept. of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 4Graduate Institute of Medical Physics and Imaging Science, Chang Gung University, Taoyuan, Taiwan; 5MRI center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

To evaluate the cerebrovascular response of normal tissues and cerebral tumors under breath-holding challenges by using 3-T blood oxygenation-level dependent (BOLD) and vascular space occupancy (VASO) MRI. Six normal adults and 14 patients with brain tumors were studied. There were significant BOLD signal increases and VASO signal decreases in normal appearing gray matter of normal subjects and patients, but not in the tumors. Interestingly, there were BOLD signal decreases or VASO signal increases in two meningiomas. Both 3-T BOLD and VASO MRI can detect breath-hold regulated cerebrovascular changes, with a higher sensitivity for signal detection of BOLD technique.