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Abstract #4306

Quantitative MRI Analysis of Aging of Human Fat Tissue: Intra-Orbital Versus Extra-Orbital Fat

Memi Watanabe1, Osamu Sakai1, Joseph Liao1, Hernan Jara1,2

1Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA, United States; 2Department of Biomedical Engineering, Boston University, Boston, MA, United States

Purpose: To study the aging pattern of intra- vs. extra-orbital fat tissue, using multispectral quantitative MR imaging (qMRI). Methods: Forty-two subjects (M:F=21:21, age: 0.5-87 years, average 31.5) were examined with experimental mixed turbo spin echo (mixed-TSE) sequence. Region-of-interest (ROI) measurements of retrobulbar fat, buccal fat and subcutaneous fat tissues were obtained for multispectral qMRI analysis. Results: PD and T1 values of all fat tissues showed similar tissue characteristics and aging patterns, while a decrease in T1 and secular-T2 values was seen in extra-orbital fat with aging. Conclusion: Multispectral qMRI data of aging in intra- and extra-orbital fat tissues were obtained.