Bing Yao1, Simon Hametner2, Peter
van Gelderen1, Hellmut Merkle1, Fredric Cantor3,
Henry McFarland3, Hans Lassmann2, Jeff H. Duyn1,
Francesca Bagnato3
1AMRI, NINDS, National Institutes of
Health, Bethesda, MD, United States; 2Centre for Brain Research,
Medical University, Vienna, Austria; 3NIB, NINDS, National
Institutes of Health, Bethesda, MD, United States
Focal
cortical grey matter lesions (CLs) are an important component of multiple sclerosis
(MS) pathology. However, detecting cortical lesions in MS using MRI poses
challenges. MRI at ultra-high field strengths such as 7 Tesla has the
potential to superbly enhance MS-induced CLs visibility. In this study, we
applied ultra-high resolution R2* maps to detect and evaluate cortical
lesions and their subtypes and the MRI results were compared with the
pathology analysis.