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Abstract #4328

A Five-Year Serial Longitudinal Study of Deep Gray Matter Atrophy in Patients with Multiple Sclerosis

Robert Zivadinov1, Dana Horakova2, Michael G. Dwyer3, Deepa Ramasamy3, Eva Havrdova2, Zdenek Seidl4, Ondrej Dolezal3, Sara Hussein3, Ellen Carl3, Manuela Vaneckova4, Niels Bergsland3

1Neurology, Buffalo Neuroimaging Analysis Center, Buffalo , NY , United States; 2Charles University, Department of Neurology, Prague, Czech Republic; 3University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; 4Charles University, Department of Radiology, Prague, Czech Republic

To compare the evolution of deep gray matter (DGM) atrophy in early relapsing-remitting (RR) multiple sclerosis (MS) patients and in normal controls (NC) over 2 years. To investigate the extent of DGM atrophy progression in MS patients over 5 years.