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Abstract #4330

Cortical N-Acetyl Aspartate Predicts Long-Term Clinical Disability in Multiple Sclerosis a Longitudinal MR Spectroscopic Imaging Study

Xingchen Wu1, Lars G. Hanson1,2, Morten Blinkenberg3, Arnold Skimminge1, Per Soelberg Srensen3, Olaf Paulson1,4, Henrik Mathiesen1,3

1Danish Research Center for Magnetic Resonance, MR Dept., Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 2Department of Electrical Engineering, Technical University of Denmark, Denmark; 3Danish MS Research Center, Neurology Dept., Copenahgen University Hospital Rigshospitalet, Denmark; 4Dept. Neurology and Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark

MR spectroscopic imaging (MRSI) provides in vivo information about neuronal loss or dysfunction by measuring N-acetyl aspartate (NAA). This aim of this multi-slice echo-planar spectroscopic imaging study was to test the hypothesis that cortical NAA/Creatine (Cr) is a potential predictor of neurological disability in relapsing-remitting multiple sclerosis (RRMS) by serial MRSI once every 6 months for 24 months. Clinical examinations including the Expanded Disability Status Scale (EDSS) were performed at baseline, month 24, and year 7. We found that baseline cortical NAA/Cr ratio was negatively correlated with EDSS at month 24 and year 7. In conclusion, cortical NAA/Cr in early RRMS predicts clinical disability in 7 years.