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Abstract #4337

Variation in Signal Surrounding White Matter Lesions in Primary Progressive Multiple Sclerosis

Daniel J. Tozer1, Abdulgabbar Hamid1, Declan T. Chard1, David H. Miller1, Alan J. Thompson2

1NMR Unit, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom

It is known that the normal appearing tissue of subjects with multiple sclerosis is abnormal, but not whether this is linked to focal white matter (WM) lesions or more widespread. This work investigates the tissue surrounding lesions for a variety of MRI parameters and compares them to the lesion and distant WM. Up to 9 pixel thick layers were extracted for MTR, T1 and T2 maps. It was found that much of this tissue is different to WM and the lesion. Hypointense and isointense lesions (on T1 weighted images) also behaved differently suggesting different pathological processes occurring at different times.