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Abstract #4341

Hypoperfusion of Brain Parenchyma Is Strongly Associated with the Severity of Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis

Paolo Zamboni1, Erica Menegatti1, Bianca Weinstock-Guttman2, Michael G. Dwyer3, Claudiu V. Schirda3, Anna M. Malagoni1, David Hojnacki2, Cheryl Kennedy3, Ellen Carl3, Niels Bergsland3, Christopher Magnano3, Ilaria Bartolomei1, Fabrizio Salvi1, Robert Zivadinov4

1University of Ferrera- Bellaria Neurosciences, Vascular Diseases Center, Ferrera, Italy; 2University at Buffalo, The Jacobs Neurological Institute, Buffalo, NY, United States; 3University at Buffalo, Buffalo Neuroimaging Analysis Center, Buffalo, NY, United States; 4University at Buffalo, Buffalo Neuroimaging Analysis Center\, Buffalo, NY, United States

Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition described in multiple sclerosis (MS) patients, characterized by stenoses of the main extracranial veins with hampered cerebral venous outflow. We hypothesized that the impaired venous outflow contributes to hypoperfusion of brain parenchyma, as measured by perfusion-weighted imaging. CCSVI was established based on the venous hemodynamic (VH) Doppler criteria. There was a significant strong association between VH criteria and PWI indices in all examined regions of the brain parenchyma in MS patients. This study demonstrates that severity of CCSVI is directly associated with hypoperfusion of the brain parenchyma in MS.