Richa Trivedi1, H Anuradha2, Atul
Agarwal2, Ram KS Rathore3, Kashi N. Prasad4,
Rajendra P. Tripathi1, Rakesh Kumar Gupta5
1NMR Research Centre, Institute of
Nuclear Medicine and Allied Sciences, Delhi, India; 2Neurology,
Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh,
India; 3Mathematics and Statistics, Indian Institute of
Technology, , Kanpur, Uttar Pradesh, India; 4Microbiology, Sanjay
Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh,
India; 5Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of
Medical Sciences, Lucknow, Uttar Pradesh, India
Diffusion
tensor tractography using FACT algorithm was performed on 20 children with
different grades of subacute sclerosing panencephalitis (SSPE) to look for
probable correlation between tract-specific DTI metrics in major white matter
pathways and Jabbour classification based clinical grades. A significant
inverse correlation was observed between fractional anisotropy (FA) in major
white matter tracts and clinical grades. We conclude that FA is a better
measure than conventional MRI for the assessment of clinical grade in these
patients.