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Abstract #4352

Characteristics of White Matter Hyperintensities in MR Images of Cerebral Amyloid Angiopathy

Junya Konishi1,2, Julien Milles2, Jeroen van der Grond2, Mark A. van Buchem2

1Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan; 2Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

MRI manifestations of cerebral amyloid angiopathy (CAA) are white matter hyperintensities (WMH) and cerebral micobleeds (CMB), and the characteristics of CAA-related WMH have not been studied before. The purpose of this study was to study the volume and distribution of CAA-related WMH using an automated method for probability maps and voxelwise statistical maps of WMH on MRI. Our study demonstrated that CMB are associated with WMH, and increased numbers are associated with increased volumes of WMH. Also we found evidence for differences in distribution of WMH associated with CAA-type CMB as compared to other types of CMB.