Abstract #4356

Multimodality Study for Restless Legs Syndrome Revealed Local Morphological Changes Associated with T2: Hypomyelination or Iron Deficiency?

Byeong-Yeul Lee¹, James R. Connor², Qing X. Yang,^1,3

¹Bioengineering, Penn State Hershye Medical Center, Hershey, PA, United States; ²Neurosurgery, Penn State Hershye Medical Center, Hershey, PA, United States; ³Radiology, Penn State Hershye Medical Center, Hershey, PA, United States

Restless leg syndrome (RLS) is a sensory-motor disorder characterized by uncontrollable urges to move the legs, causing chronic sleep disturbances. Brain iron deficiency has been considered as an important contributing factor to RLS. In this study, we applied voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based morphometry (VBM) for morphological study respectively to a same study cohort, aiming to determine the impact of iron deficiency on brain morphology. Our results revealed a striking association of local T2 change with brain atrophy.