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Abstract #4364

Measurement of Iron Concentration in Human Brain Using Quantitative Susceptibility Mapping (QSM): Correlation with Age

Tian Liu1,2, Jing Liu2, Ludovic de Rochefort3, James Ledoux2, Qing Zhang4, Martin R. Prince2, Jianlin Wu4, Yi Wang1

1Biomedical Engineering, Cornell University, New York, NY, United States; 2Radiology, Weill Cornell Medical College, New York, NY, United States; 3MIRCen, I2BM, DSV, CEA, Fontenay-aux-Roses, France; 4Radiology, The 1st Hospital of Dalian Medical University, Dalian, Liaoning, China

Increasing iron deposition with increasing age has been confirmed in postmortem studies and observed in in vivo MRI. In this 100 volunteer study, we specifically measured susceptibility in putamen, and converted it to Fe3+ concentration. A strong linear correlation was obtained between susceptibility and age. The iron concentration agreed well with postmortem results.