Abstract #4373

Thickness Profile Generation for the Corpus Callosum Using Laplace's Equation

Christopher Leslie Adamson¹, Amanda Wood^1,2, Jian Chen¹, Sarah Barton¹, David Reutens³, Mark Walterfang^4,5

¹Developmental and Functional Brain Imaging, Murdoch Childrens Research Institute, Melbourne, VIC, Australia; ²Department of Medicine, Southern Clinical School, Monash University, Melbourne, VIC, Australia; ³Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia; ⁴Neuropsychiatry Unit, Royal Melbourne Hospital, Melbourne, VIC, Australia; ⁵Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC, Australia

We present a method to generate thickness profiles of the corpus callosum from midsagittal slices of MR images. The method is mostly automated, robust and computationally efficient. We utilise the method to reveal morphological changes of the corpus callosum at different stages of schizophrenia.