Sean CL Deoni1, Evelyne Mercure2,3, Anna Blasi2,3, David Gasston1, Alex Thomson3, Mark Johnson2, Steven CR Williams1, Declan GM Murphy3
1Centre for Neuroimaging Sciences, King's College London, Institute of Psychiatry, London, United Kingdom; 2Centre for Brain and Cognitive Development, Birkbeck University of London, London, United Kingdom; 3Department of Psychological Medicine, King's College London, Institute of Psychiatry, London, United Kingdom
We report on the use of multi-component relaxation time measurement (MCR) to investigate myelination during human neurodevelopment. Using the mcDESPOT MCR technique, we present the first ever in vivo visualization of healthy white matter myelination from 3 through 8 months of age. Obtained results faithfully reproduce the spatio-temporal sequence established via post-mortem histological studies.