Abstract #4390

Evidence of Neuronal Growth Spurts During Development in Healthy Children and Adolescents Using a Multi-Voxel In Vivo 31P Spectroscopy at 4 Tesla

Jeffrey A. Stanley¹, Dalal Khatib¹, Rachel M. Dick¹, Olivia A. McGarragle¹, Frank P. MacMaster¹, Arthur L. Robin¹, David R. Rosenberg¹, Brian Martis², Vaibhav A. Diwadkar¹

¹Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States; ²Psychiatry, VA Ann Arbor HCS, University of Michigan, Ann Arbor, MI, United States

The high prevalence of the onset of many psychiatric disorders during childhood and adolescence highlights the importance of understanding the molecular biochemistry of healthy neurodevelopmental trajectories in the maturing brain. In vivo ³¹P spectroscopy is a neuroimaging method that is sensitive in detecting biochemical changes as the brain develops. The purpose of this study is to investigate changes in membrane phospholipid metabolites of healthy children and adolescents to discern developmental growth spurts in cortical and subcortical structures using in vivo ³¹P spectroscopy at a higher magnetic field strength.