Moran Artzi1,2, Liat Ben Sira3, Haim
Bassan4, Varda Gross-Tsur5,6, Irit Berger7,
Ronella Marom7, Yael Leitner4, Maya Weinstein1,8,
Ronny Geva9, Dafna Ben Bashat1
1The Wohl Institute for Advanced
Imaging, Brain Imaging Center, Tel Aviv Sourasky Medical Center, Tel-Aviv,
Israel; 2Sackler Faculty of Medicine, Tel Aviv University,
Tel-Aviv, Israel; 3Department of Radiology , Tel Aviv Sourasky
Medical Center, Tel-Aviv, Israel; 4Pediatric Neurology and Child
Development Unit, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; 5Neuropediatric
Unit, Shaare-Zedek Medical Center, Jerusalem, Israel; 6Department
of Family Medicine, Hebrew University, Jerusalem, Israel; 7Department
of Neonatology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center,
Tel-Aviv, Israel; 8Department of Psychology, Gonda
Multidisciplinary Brain Research Center, Bar Ilan University , Ramat-Gan ,
Israel; 9Department of Psychology, Gonda Multidisciplinary Brain
Research Center, Bar Ilan University, Ramat-Gan, Israel
The
ability to diagnose abnormal MR-signal in the infant's brain is challenging.
The aim of this study is to present a methodology that enables quantification
and comparison between infants' brains, by creating a standard space that
includes the imaging data and templates and atlases adjusted to infants. Preliminary
results of DTI in HIE infants with and without hypothermia (cooling to 33c
for 72 hours) compared with normal controls are presented, demonstrating the
applicability of this methodology in the pathological brain. Diffusivity
values in different VOIs and histogram analysis show the effect of the
therapeutic hypothermia in HIE.