Catherine Lebel1, Carmen Rasmussen2, Katy Wyper1, Gail Andrew3, Christian Beaulieu1
1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Pediatrics, University of Alberta, Edmonton, Alberta, Canada; 3Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada
Diffusion tensor imaging (DTI) studies of reading consistently highlight left temporal-parietal white matter. We used DTI to correlate fractional anisotropy (FA) with reading ability in 40 subjects with fetal alcohol spectrum disorder (FASD) aged 5-19 years and 40 healthy controls. The control group had three significantly correlated clusters in the left temporal-parietal area and one in the genu (all positive), in good agreement with previous findings. The FASD group had 9 clusters with significant correlations (3 negative, 6 positive). These included 3 left temporal-parietal clusters, showing consistent involvement in this area, but also demonstrating more widespread correlations than controls.