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Abstract #4403

White Matter Microstructure Correlates with Reading Ability in Healthy Subjects and Those with Fetal Alcohol Spectrum Disorder

Catherine Lebel1, Carmen Rasmussen2, Katy Wyper1, Gail Andrew3, Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Pediatrics, University of Alberta, Edmonton, Alberta, Canada; 3Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada

Diffusion tensor imaging (DTI) studies of reading consistently highlight left temporal-parietal white matter. We used DTI to correlate fractional anisotropy (FA) with reading ability in 40 subjects with fetal alcohol spectrum disorder (FASD) aged 5-19 years and 40 healthy controls. The control group had three significantly correlated clusters in the left temporal-parietal area and one in the genu (all positive), in good agreement with previous findings. The FASD group had 9 clusters with significant correlations (3 negative, 6 positive). These included 3 left temporal-parietal clusters, showing consistent involvement in this area, but also demonstrating more widespread correlations than controls.