Meeting Banner
Abstract #4414

Where Is the clinical Relevant Penumbra? a Voxel-Based Analysis in Acute Stroke Patients

Charlotte Rosso1,2, Yohan Attal2, Sophie Crozier1, Romain Valabrgue3, Dider Dormont, 2,4, Sylvain Baillet2, Stephane Lehericy3,5, Yves Samson1

1Urgences Cerebro-Vasculaires, Pitie-Salpetriere Hospital, Paris, France; 2CRICM, INSERM UMR S_975, CNRS UMR_7225, Equipe COGIMAGE, Pitie-Salpetriere Hospital, Paris, France; 3Centre for NeuroImaging Research CENIR, Pitie-Salpetrire Hospital, Paris, France; 4Neuroradiology Department, Pitie-Salpetriere Hospital, Paris, France; 5Neuroradiology Department, Pitie-Salpetriere, Paris, France

In this study, we used, in 43 MCA acute stroke patients with initial and follow-up MRI, ADC maps to study the tissue-at-risk location. To investigate this issue, time course of ADC changes between initial and follow-up MRI, impact of recanalization in final ADC-defined infarct areas, and relationship with key regions associated with poor outcome were assessed. Infarct expansion concerns perisylvian regions but also the deep MCA territory and part of the CST. The comparison of ADC maps of recanalized vs. non-recanalized and good vs. poor outcome patients shows a great overlap and involved the lenticular nucleus and the CST.