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Abstract #4417

Change in Axial and Radial Diffusional Kurtoses for Ischemic Stroke

Jens H. Jensen1, Maria F. Falangola1,2, Caixia Hu1, Ali Tabesh1, Calvin Lo1, Otto Rapalino1,3, Joseph A. Helpern1,2

1Radiology, New York University School of Medicine, New York, NY, United States; 2Center for Advanced Brain Imaging, Nathan S. Kline Institute, Orangeburg, NY, United States; 3Department of Radiology, Massachusetts General Hospital, Boston, MA, United States

Diffusional kurtosis imaging was applied to measure the axial and radial diffusional kurtoses for three patients with subacute focal ischemic stroke. For all three patients, the axial diffusional kurtoses increased substantially in the affected regions (relative to the contralateral side), but for two of the subjects, the radial diffusional kurtoses showed little change. In these two cases, the affected regions appeared to be primarily in white matter, suggesting that for white matter ischemia mainly alters the diffusional kurtosis in the axial direction.