Warren Chang1, Yijing Wu, Kevin Johnson,
Andrew Wentland2, Steven Kecskemeti3, Charles Mistretta1,
Patrick Turski1
1Radiology/Medical Physics, University
of Wisconsin School of Medicine and Public Health, Madison, WI, United
States; 2Medical Physics, University of Wisconsin School of
Medicine and Public Health, Madison , WI, United States; 3Physics/Medical
Physics, University of Wisconsin School of Medicine and Public Health,
Madison, WI, United States
Time-average
wall shear stress in the M1 segment of the middle cerebral arteries of 10
healthy volunteers was calculated using automated spline interpolation. The
velocity measurements were acquired using PC-VIPR, a fast undersampled phase-contrast
MRA technique that allows whole-brain imaging in 5 minutes with
sub-millimeter spatial resolution. The
calculated average WSS for the proximal MCA was 0.20 Pa (S.D. 0.016 Pa)
consistent with published values for PC-MRA. This report shows that fast,
automated, non-invasive estimation of wall shear stress can be obtained in
middle and large-sized intracranial arteries that are prone to the
development of atherosclerosis and other cerebrovascular disorders.
Keywords