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Abstract #4432

High Field in Vivo Magnetic Resonance Imaging of Lenticulostriate Arteries in CADASIL

Michael K. Liem1, Saskia A.J. Lesnik Oberstein2, Maarten J. Versluis1, Joost Haan3, Andrew G. Webb1, Michel D. Ferrari3, Mark A. van Buchem1, Jeroen van der Grond1

1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands; 3Neurology, Leiden University Medical Center, Leiden, Netherlands

In this study we examined luminal diameters of lenticulostriate arteries in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Twenty-two CADASIL patients and 11 controls were examined using high resolution 3D-time-of-flight magnetic resonance angiography (TOF MRA) imaging on a 7-Tesla MRI scanner. No differences between CADASIL patients and controls were found in length, total number or total cross-sectional area of lenticulostriate artery lumina. Measurements of lenticostriate arteries were not associated with lacunar infarct load in the basal ganglia area.