Meeting Banner
Abstract #4435

Flow Residence Time Predicts the Location of Intra-Aneurysmal Thrombus: Numerical Modeling Based on MRA and MRV Data

Vitaliy L. Rayz1, Loic Boussel2, Liang Ge3, Joe R. Leach1, Alastair J. Martin1, Michael T. Lawton4, David Saloner1

1Radiology, University of California San Francisco, San Francisco, CA, United States; 2Creatis-LRMN (LB, PCD), Lyon, France; 3Surgery, University of California San Francisco; 4Neurological Surgery, University of California San Francisco

Thrombus deposition in cerebral aneurysms presents an increased risk of thrombo-embolism. The effect of increased flow residence time (RT) on thrombus deposition was investigated using a new numerical flow visualization technique. MR angiography and MR velocimetry data were used to construct patient-specific numerical models of the flow in three basilar aneurysms with known regions of thrombus deposition. The flow RT maps computed with CFD in the base-line geometries were compared with intra-aneurysmal regions that were observed to clot at the follow-up MRI studies. The results show that intra-aneurysmal regions with increased flow residence time are prone to thrombus deposition.