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Abstract #4438

Increased Detectability of Alzheimer Plaques at 7T Vs. 3T Using High Resolution BSSFP

Michael Zeineh1, Hagen Kitzler2, Scott Atlas1, Brian Rutt1

1Radiology, Stanford University Medical Center, Stanford, CA, United States; 2Neuroradiology, Technische Universitaet Dresden, Dresden, Germany

Beta amyloid plaques may have a significant role in the development of Alzheimers disease. MRI has been used to visualize these plaques in humans ex vivo, but the etiology of the signal changes associated with plaques is unclear. We imaged 5 human AD specimens and 5 normal specimens at 3.0T and 7.0T with a 3.5 hour bSSFP sequence tailored to visualize plaques. While image SNR was approximately 1.7 times higher at high field, presumed plaque CNR was three times higher. This nonlinear increase may be explained by a field-sensitive microscopic component of amyloid plaques.