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Abstract #4442

MEG-Guided Surface Coil Imaging at 3 Tesla in Patients with Refractory Epilepsy: Preliminary Results

Samuel Lapere1, Evelien Carrette2, Paul Boon2, Kristl Vonck2, Xavier De Tige3, Eric Achten1, Karel Deblaere1

1Department of Radiology, Ghent University Hospital, Ghent, Belgium; 2Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital; 3Laboratoire de Cartographie Fonctionelle du Cerveau, ULB Erasmus Hospital Brussels, Belgium

Patients with refractory epilepsy in whom the epileptogenic zone cannot be precisely identified are not likely to undergo resective surgery. This study aims to assess the potential of surface coil imaging at 3T guided by magnetoencephalography (MEG) to locate the epileptogenic zone. Fifteen patients with dipole clustering on MEG (indicating the possible epileptogenic zone) were scanned with a surface coil at 3T. MEG-guided surface coil imaging at 3T showed an added value in the detection of lesions previously not visible or missed on 3T MRI, and demonstrated an improved delineation and electrophysiological validation of previously known lesions.