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Abstract #4444

High Resolution Magnetization Transfer Imaging at 3T VS. 1.5T

Ying Wu1,2, Christine O'Brien3, Christopher Glielmi4, Hongyan Du5, Robert Edelman2,3, Ann Ragin6

1Radiology , NorthShore University HealthSystem, Evanston, IL, United States; 2Radiology , University of Chicago; 3Radiology, NorthShore University HealthSystem, Evanston, IL, United States; 4Cardiovascular MR R&D, Siemens Healthcare; 5NorthShore University HealthSystem Research Institute; 6Radiology, Northwestern University

The increased field strength at 3T significantly improved image quality of high resolution Magnetization Transfer Images, while the increased scan variation at higher field strength is a potential concern; this investigation indicated that relative to 1.5T, the 3T scanner is conducive to more consistent MTR measurement over time. Importantly, our findings in the human study indicate excellent reproducibility in regions such as the hippocampus that are critical regions for detecting early changes in Alzheimers disease and other neurological disorders. Our results demonstrate the promising potential of high resolution MT for clinical application.