Abstract #4451

Vessel Contrast in Susceptibility Weigthed Imaging (SWI) Under Inhalated Anesthesia with Different Oxygen Pressure

Marina Benito¹, Alexia Rodrguez-Ruano², Cristina Chavarrias¹, Paula Montesinos¹, Manuel Desco¹

¹Unidad de Medicina y Ciruga Experimental, Hospital General Universitario Gregorio Maran, Madrid, Spain; ²Unidad de Medicina y Ciruga Experimental , Hospital General Universitario Gregorio Maran, Madrid, Spain

SWI allows to delineate the cerebral veins in high quality, however during the MRI exam animals are anaesthetized. Anesthetics make vary the venous contrast depending on the deepness of anesthesia, but when using inhalated anesthesia the venous response on SWI also depends on the partial pressure of oxygen (pO2) in the supplied gas. This study investigates how the pressure of oxygen in the supplied gas affects the venous contrast in SWI in order to study the microvasculature of the rat brain.